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Sleep disorders

Circadian rhythm: when your body clock is out of time.

Falling asleep at dawn and not being able to get up, falling asleep in the middle of the afternoon or changing your schedule every day is not always a matter of willpower. Youbiological clock it may be out of adjustment, and it is treated.

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Dr. Diego García-BorregueroContent reviewed byDr. Diego García-Borreguero· Medical direction

In short

Ourbiological clock it marks when we are asleep and when we are awake, synchronized especially by light. When that clock is out of adjustment or does not fit with the schedules of life, thecircadian rhythm disorders: It is not insomnia or laziness, it is a problem ofinternal schedulewhich is corrected with light, well-regulated melatonin and routines.

What is it

A problem of schedule, not quantity

The circadian rhythm is the 24-hour cycle that regulates sleep, wakefulness, temperature and many body functions. It adjusts every day thanks to external signals, especially thelight. When the internal clock goes forward, slow, or loses stability, the person sleeps.at the wrong time: You can sleep well, but at the wrong time.

The typical thing is not being able to sleep until very late and having a hard time getting up (phase delay), or on the contrary, falling exhausted early and waking up at dawn (phase advance). Shift work and travel with jet lag also throw off the clock.

The consequence is fatigue, poor performance and conflict with school or work schedules. The key to treatment is not “sleeping more,” butreset the clock.

Circadian rhythms

Circadian rhythms and sleep

Sleep, like other functions of the body (hormones, metabolism, etc.), is regulated by the so-calledbiological clock: a neuronal center located in the cerebral hypothalamus whose function is to give the signal to the rest of the brain to start and end sleep. In this way, the clock establishes at what time the propensity to sleep increases and at what time it decreases.

When activated, the biological clock sends a signal to the pineal gland to begin production ofmelatonin, the hormone that coordinates the body adapting so that sleep can begin.

Under normal conditions, the clock is synchronized with external luminosity through the retina. Thus, as the day ends and the light decreases, drowsiness appears a few hours later. However, exposure toartificial light typical of the modern worldand, more recently, to televisions, computers, tablets and mobile phones at night, can delay the activation of the brain centers that regulate sleep for several hours.

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Types

Types of circadian rhythm disorder

Tap each one to get to know them:

Phase delay syndrome

Common in young peopleExtreme 'Owl'

The clock is slow: the person does not fall asleep until dawn and has a hard time getting up in the morning. If you sleep on time, you rest well. Very common in adolescents.

Phase advancement syndrome

More common in older people

The clock is fast: irresistible sleep in the early evening and waking up in the early morning without being able to go back to sleep. More common with age.

Shift work disorder

Labor

Working at night or rotating forces you to sleep against the internal clock, causing insomnia and drowsiness. Exposure to light, strategic naps and schedules are worked on.

Jet lag

Temporary

When crossing time zones, the clock takes days to reset. With light guidelines and, sometimes, melatonin, adaptation is accelerated.

Irregular sleep-wake rhythm

No fixed pattern

Sleep is divided into several sections without a stable schedule. It is seen in some neurological situations and improves by reinforcing routines and daylight.

Types by rhythm

Types of insomnia linked to a disrupted sleep–wake rhythm

Rhythm disorders manifest themselves in different ways. The common denominator is that the amount of sleep may be normal, but it occurs at the wrong time:

Phase delay syndrome.The person has difficulty falling asleep at the usual hours (for example, at 11 or 12 at night): at that time they are completely awake and sleep only comes hours later, well into the early morning. Once she falls asleep, she does so deeply. If you have to get up early, you sleep few hours, you feel tired and have poor performance in the morning. In mild cases it can manifest itself simply by sleeping 1 or1.5 hours lessthan it should; In more severe forms, falling asleep at 4 or 5 in the morning.

Phase advancement syndrome. it is the opposite situation: the cycle begins early (for example, at 8 in the afternoon) and also ends early, with waking up completely sleepless in the early morning. It is more common in older people and can occur in families with an associated gene.

Irregular sleep rhythm.Sleep is fragmented into episodes that never exceed several hours, randomly both at night and during the day. It occurs mainly in some neurological disorders; In its minor form, any chronic insomnia can end up having a certain irregular component.

Jet lag. it occurs when crossing suddenlythree or more time zones. Between the United States and Europe there are six or more hours of difference. The biological clock continues to mark the time of origin: a traveler who leaves Boston at 7 in the afternoon and lands in Madrid at 9 in the morning (local time) has the body functioning as if it were 3 in the morning. Adaptation occurs slowly, approximately1.5 hours per dayelapsed. It does not depend on the duration of the flight, but exclusively on the number of time zones crossed.

Why it happens

What monthses up the clock?

The internal clock is synchronized with the environment; When those signals fail, it becomes unbalanced.

Lack of daylight

Little light during the day and a lot of light at night throws off the clock.

Irregular hours

Go to bed and get up at different times each day.

Shift work

It forces you to sleep against the natural rhythm.

night screens

Blue light delays the signal to fall asleep.

Predisposition

There are chronotypes that are more 'owl' or more 'lark'.

Age and health

The clock changes with age and certain diseases.

Why it happens

Factors that alter the clock

The biological clock can be out of adjustment for multiple reasons, some internal and others external.

Genetic factors

Several genes ("clock genes") are involved in the circadian rhythm; Any anomaly can make it difficult to sleep at certain times.

Hormonal factors

Menstruation, menopause, pregnancy, use of oral contraceptives and endocrinological diseases can alter the clock.

Drugs

Some antidepressants and blood-pressure medicines, among others, disrupt the sleep–wake rhythm.

Ophthalmological disorders

Any problem that hinders the transmission of the light signal through the retina desynchronizes the clock.

Neurological disorders

Various neurological conditions can disrupt the rhythm.

Food and exercise

Eating habits and physical activity also influence clock synchronization.

Brain clock

How do you know if insomnia is due to the brain clock?

Frequently, insomnia is not only due to poor stress management, but also to an abnormal functioning of the biological clock. If you can sleep well, but not at the time you want, you may have a sleep rhythm disorder. Some people sleep well between6 and 14, or between19 and 2in the morning, but they cannot sleep when they try to do so between 11 and 7 in the morning.

Signs that insomnia may mainly come from a disrupted sleep–wake rhythm:

  • Difficulties initiating or maintaining sleep, especially at the beginning of the night, to a much lesser extent if you try at other times.
  • The problem began in adolescence or even childhood.
  • The problem occurs almost daily, regardless of the stress level or environment.
  • It gets worse when crossing multiple time zones.
  • Improves with the administration of melatonin.
  • It is associated with daytime hypersomnolence: there is no difficulty sleeping at certain times of the day.
  • There are family members affected by a similar problem.
How we study it

Diagnosis at the Sleep Research Institute

We study your real pattern with asleep scheduleand, if necessary, actigraphy (a bracelet that records sleep and activity for several days).

1
First consultation

History of sleep, schedules and chronotype

2
Agenda / actigraphy

We record your real pace for days

3
Diagnosis

We identify the type of mismatch

4
Treatment

Light, scheduled melatonin and tailored routines

Treatment

Reset your internal clock

The treatment does not consist of taking sleeping pills, but ratherreeducate the clock. The main tools areluz(seek it or avoid it at the appropriate times, with phototherapy if appropriate),melatoninascheduled at the correct time - its effect depends a lot on the moment in which it is taken - and someschedule routinesstable.

We design a personalized plan according to your type of imbalance, your chronotype and your obligations (studies, work, shifts). In shift work and jet lag we also give specific strategies for light and naps. With consistency, most people manage to sleep at the time they need.

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My teenage son didn't sleep until four and failed for not making it to class. They explained to us that it was a phase delay; With the light and melatonin regimen he has regained a normal schedule.

P.M.
Pilar M.· mother of patient · Madrid
★★★★★
FAQ

We solve your doubts

Is this the same as insomnia?
No. With insomnia it is difficult to sleep even at the right time. In circadian rhythm disorders, people sleep well, but at the wrong time: the problem is the timing of the internal clock, and the treatment is different.
Will melatonin be good for me?
It can be very useful in these disorders, but its effect depends greatly on the dose and especially the time at which it is taken. Badly planned, it doesn't work. That is why it is advisable to adjust it with a specialist.
I work at night and sleep badly, is there a solution?
Yes. We cannot change your shift, but we can give you light strategies, naps and schedules that greatly improve rest and performance.
What is actigraphy?
It is a bracelet that you wear for several days and it records your periods of sleep and activity. It allows us to see your real rhythm without having to sleep in the clinic.
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Dr. Diego García-Borreguero
Dr. Diego García-Borreguero
Medical Director Sleep Neurology

Content reviewed by the medical team of the Sleep Research Institute.

✓ Medically reviewed

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