Publicaciones científicas

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Raptis C, Garcia-Borreguero D, Weber M, Dose M, Bremer D, Emrich HM (1989): Anticonvulsants as Adjuncts for the Neuroleptic Treatment of Schizophrenic Psychoses: A Clinical Study with Beclamide. ACTA PSYCHIATRICA SCANDINAVICA 81:162-167.

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Bossert S, Dose M, Emrich HM, Garcia-Borreguero D, Junker M, Raptis K, Weber M (1990): Psychologische Wirkungen von Behandlungsvorerfahrungen mit Neuroleptika. NERVENARZT 61:301-305.

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Lauer CJ, Garcia-Borreguero D, Pollmächer T, Ozdaglar A, Krieg JC (1990): All Night EEG Sleep in Anxiety Disorders and Major Depression. In Horne J (ed.): Sleep’90, Pontenagel Press, Bochum, pp. 229-231.

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Emrich HM, Weber M, Garcia-Borreguero D (1990): Neuere systemtheoretische Konzepte zur Therapie chronisch defektuoser Psychosen . In Möller HJ, Pelzer E (eds.): Neuere Ansätze zur Diagnostik und Therapie schizophrener Minussymptomatik. Springer Verlag, Bonn, pp. 91-99.

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Garcia-Borreguero D, Bronisch T, Apelt S, Yassouridis A, Emrich HM (1991): Treatment of Benzodiazepine Withdrawal Symptoms with Carbamazepine. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,
241:145-150.

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Bronisch T, Garcia-Borreguero D, Wolf R, Flett S, Hiller W (1992). The Munich Diagnostic Checklist for the Assessment of DSM-III-R Personality Disorders for Use in Routine Clinical Care and Research.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 242:77-81.

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Lauer CJ, Krieg JC, Garcia-Borreguero D, Ozdaglar A, Holsboer F (1992): Panic Disorder and Major Depression: A Comparative Electroencephalographic Study. PSYCHIATRY RESEARCH, 44:41-54.

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Garcia-Borreguero D, Lauer CJ, Ozdaglar A, Holsboer F, Krieg JC (1992): Brofaromine in Panic Disorder: A Pilot Study with a New Reversible Inhibitor of Monoamine Oxidase-A. PHARMACOPSYCHIATRY, 25:261-264.

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Bronisch T, Flett S, Garcia-Borreguero D, Wolf R (1993). Comparison of a Self-Rating Questionnaire with a Diagnostic Checklist for the Assessment of DSM-III-R Personality Disorders.PSYCHOPATHOLOGY, 26:102-107.

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Garcia-Borreguero D, Bronisch T: Improvement of Social Phobic Symptoms after Treatment with Brofaromine, a Reversible and Selective Inhibitor of MAO-A (letter to the editor). EUROPEAN PSYCHIATRY, 7:93-94.

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Rosenthal NE, Garcia-Borreguero D, Schwartz PJ, Jacobsen FM, Joseph-Vanderpool JR, Oren DA, Murphy DL (1994). Seasonal Affective Disorder, Light Therapy, and the Serotonin System. Proceedings of the IX World Congress of Psychiatry.World Scientific Publishing Co. Pte. Ltd.

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Friedman TC, Garcia-Borreguero D, Hardwick D, Akuete CN, Stambuk MK, Dorn LD, Starkman MN, Loh YP, Chrousos GP (1994). Diurnal Rhythm of Plasma Sleep-Inducing Peptide in Humans: Evidence for Positive Correlation with Body Temperature and Negative Correlation with REM and Slow Wave Sleep. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 78:1085-1089.

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Ozaki N, Rosenthal NE, Mazzola P, Chuang CC, García-Borreguero D, Schwartz PJ, Turner E, Oren DA, Murphy DL. Platelet [3H]Paroxetine Binding, 5-HT-Stimulated Ca2+ Response, and 5-HT Content in Winter Seasonal Affective Disorder. BIOLOGICAL PSYCHIATRY, 36:458-466.

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Lammers CH, Garcia-Borreguero D, Schmider J, Gotthardt U, Dettling M, Holsboer F, Heuser IJ. Combined dexamethasone/corticotropin-releasing hormone test in patients with schizophrenia and in normal controls: II. BIOLOGICAL PSYCHIATRY, 38 (12): 803-807.

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Friedman TC, Garcia-Borreguero D, Hardwick D, Akuete CN, Doppman JL, Dorn LD, Barker CN, Yanovski JA, Chrousos GP (1994). Decreased Delta Sleep and Plasma Delta Sleep-Inducing Peptide in Patients with Cushing Syndrome: Evidence against a Causative Role. NEUROENDOCRINOLOGY, 60:626-634.

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Garcia-Borreguero D, Jacobsen FM, Murphy DL, Joseph-Vanderpool JR, Chiara A, Rosenthal NE (1995). Hormonal Responses to the Administration of m-Chlorophenylpiperazine in Patients with Seasonal Affective Disorder and Controls.BIOLOGICAL PSYCHIATRY, 37:740-749.

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Garcia-Borreguero D (1996). Monitorización de la erección durante el sueño. En Saenz de Tejada y Gorman I, Allona Almagro A (eds.): Erección, eyaculación y sus trastornos. Editorial Iberia Salud, 1996, pp.155-172.

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Schwartz PJ, Murphy DL, Wehr TA, García-Borreguero D, Oren DA, Moul DE, Ozaki N, Snelbaker AJ, Rosenthal NE (1997): Effects of m-CPP infusions in patients with seasonal affective disorder and healthy controls: Diurnal responses and nocturnal regulatory controls. ARCHIVES OF GENERAL PSYCHIATRY, 54: 375-385.

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Garcia-Borreguero D: Organización de un Centro de Sueño (1997): NEUROLOGIA, 12 (supl.3): 8-13.

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García-Borreguero D, Dale JK, Rosenthal EN, Chiara A, O’Fallon A, Bartko JJ, Straus SE (1997): Lack of seasonal variation of symptoms in patients with chronic fatigue syndrome. PSYCHIATRY RESEARCH; 72(4): 241-249.

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García-Borreguero y Díaz-Varela D: El sueño. Mecanismos de regulación y sus trastornos. En: Desafíos del Conocimiento ante el Tercer Milenio. Fundación Central-Hispano, Madrid, 1997.

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García-Borreguero y Díaz-Varela D (1997): Función afectiva y sueño. VIGILIA/SUEÑO, 9 (2): 1-5.

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Santamaría J, Poza JJ, Zarranz JJ, Pareja JA, Salas X, García-Borreguero D (1998): Técnicas implicadas en el diagnóstico y tratamiento de los trastornos del sueño. Informe del Grupo de Estudio sobre Trastornos de la Vigilia y del Sueño de la Sociedad Española de Neurología. NEUROLOGÍA 12 (9):395-403.

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García-Borreguero D, Dale JK, Rosenthal EN, Chiara A, O´Fallon A, Bartko JJ, Straus SE (1998): Lack of seasonal variation of symptoms in patients with chronic fatigue syndrome. PSYCHIATRY RES: 77(2):71-7.

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McKenzie R, O´Fallon A, Dale J, Demitrack M, Sharma G, Deloria M, Garcia-Borreguero D, Blackwelder W, Straus SE (1998): JAMA. 1998; 280(12):1061-6.

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Caminero A, Pareja J, Garcia-Borreguero D (1998): Cronobiología. PSIQUIATRÍA BIOLÓGICA; 6:231-239.

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Schwartz PJ, Turner EH, Garcia-Borreguero D, Sedway J, Vetticad RG, Wehr TA, Murphy DL, Rosenthal NE (1999) Serotonin hypothesis of winter depression: behavioral and neuroendocrine effects of the 5-HT(1A) receptor partial agonist ipsapirone in patients with seasonal affective disorder and healthy control subjects. PSYCHIATRY RES; 86(1):9-28.

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García-Borreguero D, Wehr TA, Larrosa O, Granizo JJ, Hardwick D, Chrousos GP, Friedman TC (2000) Glucocorticoid Replacement is Permissive for REM Sleep and Sleep Consolidation in Patients with Adrenal Insufficiency. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM; 85:4201-4206.

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Garcia-Borreguero D (2000) Article reviewed: Attenuated sensitivity to neuractive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice. SLEEP MEDICINE 2000;1(2):159-160.

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Garcia-Borreguero D (2001): Article reviewed: Improvement of sleep architecture in Parkinson´s Disease with subthalamic nucleus stimulation. SLEEP MEDICINE 2: 75-76.

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Garcia-Borreguero D (2001): Effects of subthalamic nucleus stimulation on sleep and nighttime motor disability in patients with PD. SLEEP MEDICINE, 2:353-354.

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Garcia-Borreguero D, Larrosa O, Bravo M (2001): Parkinson´s disease and Sleep. SLEEP MEDICINE REVIEWS, 7 (2):115-129.

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Garcia-Borreguero D (2001): Avances en el Diagnóstico y Tratamiento del Síndrome de Piernas Inquietas (editor). VIGILIA-SUEÑO, 13, (Suppl.1).

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García-Borreguero D (2001): El síndrome de piernas inquietas: Un cuadro demasiado importante para permanecer en el olvido. VIGILIA-SUEÑO, 13 (Supl.1): S7-8.

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Bravo M, Garcia-Borreguero D (2001): Tratamiento no-dopaminérgico del síndrome de piernas inquietas. VIGILIA-SUEÑO, 13 (Supl.1): S43-49.

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Garcia-Borreguero D (2001) Article reviewed: Restless Legs Syndrome: a clinical study in general Chilean population and in uremic patients. SLEEP MEDICINE 2001;1(2):557-559.

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Garcia-Borreguero D, Larrosa O, de la Llave Y (2002): Circadian aspects in the pathophysiology of the RestlesssLegs Syndrome. SLEEP MEDICINE 3 (Suppl.1):S17-S21.

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Larrosa O, de la Llave Y, Barrio S, Granizo JJ, Garcia-Borreguero D (2001):Stimulant and anticataplectic effects of reboxetine in patients with narcolepsy. A pilot study.SLEEP 2001;24(3)282-285.

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Larrosa O, de la Llave Y, Barrio S, Granizo JJ, Garcia-Borreguero D (2001):Stimulant and anticataplectic effects of reboxetine in patients with narcolepsy. A pilot study. SLEEP 2001;24(3)282-285.

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Garcia-Borreguero D, Caminero AB, De La Llave Y, Larrosa O, Barrio S, Granizo JJ, Pareja JA. (2002): L-dopa increases phasic and tonic EMG activity during REM sleep in previously untreated patients with Parkinson´s Disease. MOVEMENTS DISORDERS, 17(5):934-41.

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Garcia-Borreguero D, Larrosa O, de la Llave Y, Verger K, Masramon X, Hernandez G (2002): Treatment of restless legs syndrome with gabapentin: A double-blind, cross-over study. NEUROLOGY, 59(10):1573-9.

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Larrosa O, Garcia-Borreguero D (2002): Somnolencia y tráfico en Europa. VIGILIA-SUEÑO, 14 (1) (Supl.); S9-S13.

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Barbato G, Fagioli I, Garcia-Borreguero D, Wehr TA (2002): Homeostatic and circadian regulation of sleep under 90 minute (30 : 60 sleep : wake) day protocol. J NEUROPHYSIOLOGY, 25:111-115.

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Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisir J, and the participants of the RLS diagnosis and epidemiology workshop at the National Institutes of Health (2003): Restless Legs Syndrome: diagnostic criteria, special considerations, and epidemiology. SLEEP MEDICINE 4 (2003):101-119.

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Garcia-Borreguero D, Odin P, Serrano C (2003): Restless Legs Syndrome and Parkinson´s disease: A review of the evidence for a possible association. NEUROLOGY, 61 (Suppl 3):S49-S55.

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Garcia-Borreguero D, Serrano C, Larrosa O (2003): Overview and Diagnosis of Restless Legs Syndrome. CURRENT CHALLENGES IN PARKINSON´S DISEASE AND RESTLESS LEGS SYNDROME, 7-8. 2002 EFNS Congress.

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Estivill E, Bove A, Garcia-Borreguero D, Gibert J, Paniagua J, Pin G, Puertas FJ, Cilveti R (2003): Consensus on Drug Treatment, Definition ands Diagnosis for Insomnia. CLIN DRUG INVEST 23 (6):351-385.

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Garcia-Borreguero D, Larrosa O, Serrano C (2003): Conceptos actuales en torno a la Fisiopatología del Síndrome de Piernas Inquietas. PARKINSON Y TRASTORNOS DEL MOVIMIENTO, 5:37-38.

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Garcia-Borreguero D (2003): Augmentation: Understanding a key feature of RLS (Editorial). SLEEP MEDICINE, 5(1):5-6.
Estivill E, Bové A, García-Borreguero D, Gibert J, Paniagua J, Pin G, Puertas FJ, Cilveti R; members of the Consensus Group Consensus on drug treatment, definition and diagnosis for insomnia.CLIN DRUG INVESTIG.2003;23(6):351-85.

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Garcia-Borreguero D, Schwarz C, Odin P (2004): Restless Legs Syndrome: An Overview of the Current Understanding and Management. ACTA NEUROLOGICA SCANDINAVICA, 109(5):303-17.

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Garcia-Borreguero D, Schwarz C, Larrosa O, de la Llave Y, Garcia de Yébenes J (2004):L-DOPA induced Excessive Daytime Sleepiness in PD: A Placebo-Controlled Case with MSLT-Assessment (Reply from the Authors). NEUROLOGY, 61(7):1008-10.

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Trenkwalder C, Garcia-Borreguero D, Montagna P, Lainey E, de Weerd AW, Tidswell P, Saletu-Zyhlarz G, Telstad W and Ferini-Strambi L (2004): Ropinirole in the treatment of restless legs syndrome: results from a 12-week, randomised, placebo-controlled study in 10 European countries. JOURNAL OF NEUROLOGY, NEUROSURGERY & PSYCHIATRY, 7(5):92-97.

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Serrano C, Garcia-Borreguero D (2004): Fluctuations in cognition/ alertness in Parkinson´s disease and dementia. NEUROLOGY, 63 (Suppl. 3):S31-S34.

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Garcia-Borreguero D, Larrosa O, Granizo JJ, de la Llave Y, Hening WH (2004): Circadian variation of neuroendocrine response to L-DOPA in Restless Legs Syndrome. SLEEP, 2004;27:669-673.

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Garcia-Borreguero D, Serrano C, Egatz R (2004): Diagnosis of the Restless Legs Syndrome: The use of the sleep laboratory In: KR Chaudhuri, P Odin, CW Olanow, editors. Restless Legs Syndrome. London: Tayor & Francis, 2004: 113-134.

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Garcia-Borreguero D, Egatz R, Larrosa O (2004): Supresión del sueño REM y efectos antidepresivos. VIGILIA-SUEÑO,

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Garcia-Borreguero D, Serrano C, Larrosa O, Granizo JJ (2004): Circadian Effects of Dopaminergic Treatment in Restless Legs Syndrome. SLEEP MEDICINE, 5(4):413-20.

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Garcia-Borreguero D (2005): Overview of the pathophysiology of the restless legs syndrome. REV MED UNIV NAVARRA 49(1):10-17
Vignatelli L, Billiard M, Clarenbach P, Garcia-Borreguero D, Kaynak D, Liesiene V, Trenkwalder C, Montagna P; EFNS Task Force. EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep.EUR J NEUROL. 2006 Oct;13(10):1049-65.

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Garcia-Borreguero D. Time to REST: epidemiology and burden.
EUR J NEUROL. 2006 Oct;13 Suppl 3:15-20.

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Garcia-Borreguero D, Egatz R, Winkelmann J, Berger K.Epidemiology of restless legs syndrome: the current status.SLEEP MED REV. 2006 Jun;10(3):153-67.

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Abetz L, Arbuckle R, Allen RP, Garcia-Borreguero D, Hening W, Walters AS, Mavraki E, Kirsch JM. The reliability, validity and responsiveness of the International Restless Legs Syndrome Study Group rating scale and subscales in a clinical-trial setting.SLEEP MED. 2006 Jun;7(4):340-9.

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Zucconi M, Ferri R, Allen R, Baier PC, Bruni O, Chokroverty S, Ferini-Strambi L, Fulda S, Garcia-Borreguero D, Hening WA, Hirshkowitz M, Högl B, Hornyak M, King M, Montagna P, Parrino L, Plazzi G, Terzano MG International Restless Legs Syndrome Study Group (IRLSSG). The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Group (IRLSSG).SLEEP MED. 2006 Mar;7(2):175-83.

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Garcia-Borreguero D, : Periodic Leg Movements of Sleep. In: Culebras A: Neurology of Sleep, Wiley & Sons, NY, in press.Garcia-Borreguero D,: Restless Legs Syndrome.

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García-Borreguero D, Allen RP, Kohnen R, Högl B, Trenkwalder C, Oertel W, Hening WA, Paulus W, Rye D, Walters A, Winkelmann J, Earley CJ; International Restless Legs Syndrome Study Group. Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute.. SLEEP MED. 2007;8(5):520-30.

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García-Borreguero D, Kohnen R, Högl B, Ferini-Strambi L, Hadjigeorgiou GM, Hornyak M, de Weerd AW, Happe S, Stiasny-Kolster K, Gschliesser V, Egatz R, Cabrero B, Frauscher B, Trenkwalder C, Hening WA, Allen RP. Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome.SLEEP MED. 2007;8(5):455-63.

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Kohnen R, Allen RP, Benes H, Garcia-Borreguero D, Hening WA, Stiasny-Kolster K, Zucconi M. Assessment of restless legs syndrome–methodological approaches for use in practice and clinical trials.MOV DISORD.2007;22 Suppl 18:S485-94.

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Trenkwalder C, Kohnen R, Allen RP, Benes H, Ferini-Strambi L, Garcia-Borreguero D, Hadjigeorgiou GM, Happe S, Högl B, Hornyak M, Klein C, Nass A, Montagna P, Oertel WH, O’Keeffe S, Paulus W, Poewe W, Provini F, Pramstaller PP, Sieminski M, Sonka K, Stiasny-Kolster K, de Weerd A, Wetter TC, Winkelmann J, Zucconi M. Clinical trials in restless legs syndrome–recommendations of the European RLS Study Group (EURLSSG).MOV DISORD. 2007;22 Suppl 18:S495-504.

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Garcia-Borreguero D, Grunstein R, Sridhar G, Dreykluft T, Montagna P, Dom R, Lainey E, Moorat A, Roberts J. A 52-week open-label study of the long-term safety of ropinirole in patients with restless legs syndrome.SLEEP MED. 2007 Nov;8(7-8):742-52.

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Garcia-Borreguero D, Winkelman J, Adams A, Ellis A, Morris M, Lamb J, Layton G, Versavel M; Sumanirole in RLS Study Group.Efficacy and tolerability of sumanirole in restless legs syndrome: a phase II, randomized, double-blind, placebo-controlled, dose-response study.SLEEP MED. 2007;8(2):119-27.

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Trenkwalder C, Oertel WH, Allen R, Garcia-Borreguero D. Tireless work on restless legs: guest editors’ introduction.MOV DISORD. 2007;22 Suppl 18:S393-4.

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García-Borreguero D, Allen RP, Benes H, Earley C, Happe S, Högl B, Kohnen R, Paulus W, Rye D, Winkelmann J. Augmentation as a treatment complication of restless legs syndrome: concept and management.MOV DISORD. 2007;22 Suppl 18:S476-84.

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Trenkwalder C, Oertel WH, Allen R, Garcia-Borreguero D. Tireless work on restless legs: guest editors’ introduction. MOV DISORD. 2007;22 Suppl 18:S393-4

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García-Borreguero D, Allen RP, Benes H, Earley C, Happe S, Högl B, Kohnen R, Paulus W, Rye D, Winkelmann J. Augmentation as a treatment complication of restless legs syndrome: concept and
management.MOV DISORD. 2007;22 Suppl 18:S476-84.

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García-Borreguero D, Allen RP, Kohnen R, Högl B, Trenkwalder C, Oertel W, Hening WA, Paulus W, Rye D, Walters A, Winkelmann J, Earley CJ; International RestlessLegs Syndrome Study Group.
Diagnostic standards for dopaminergic augmentation of restless legs syndrome:report from a World Association of Sleep Medicine-International Restless LegsSyndrome Study Group consensus conference at the Max Planck Institute.SLEEP MED. 2007;8(5):520-30

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García-Borreguero D, Kohnen R, Högl B, Ferini-Strambi L, Hadjigeorgiou GM, Hornyak M, de Weerd AW, Happe S, Stiasny-Kolster K, Gschliesser V, Egatz R, Cabrero B, Frauscher B, Trenkwalder C, Hening WA, Allen RP.Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric,prospective study with levodopa on restless legs syndrome.SLEEP MED. 2007;8(5):455-63.

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Kohnen R, Allen RP, Benes H, Garcia-Borreguero D, Hening WA, Stiasny-Kolster K, Zucconi M.Assessment of restless legs syndrome–methodological approaches for use inpractice and clinical trials.. MOV DISORD. 2007;22 Suppl 18:S485-94

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Trenkwalder C, Kohnen R, Allen RP, Benes H, Ferini-Strambi L, Garcia-Borreguero D, Hadjigeorgiou GM, Happe S, Högl B, Hornyak M, Klein C, Nass A, Montagna P, Oertel WH, O’Keeffe S, Paulus W, Poewe W, Provini F, Pramstaller PP, Sieminski M, Sonka K, Stiasny-Kolster K, de Weerd A, Wetter TC, Winkelmann J, Zucconi M. Clinical trials in restless legs syndrome–recommendations of the European RLSStudy Group (EURLSSG). . MOV DISORD. 2007;22 Suppl 18:S495-504

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Trenkwalder C, Benes H, Poewe W, Oertel WH, Garcia-Borreguero D, de Weerd AW, Ferini-Strambi L, Montagna P, Odin P, Stiasny-Kolster K, Högl B, Chaudhuri KR, Partinen M, Schollmayer E, Kohnen R; SP790 Study Group. Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised, double-blind, placebo-controlled trial.LANCET NEUROL. 2008 Jul;7(7):595-604.

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Oertel WH, Benes H, Garcia-Borreguero D, Geisler P, Högl B, Trenkwalder C, Tacken I, Schollmayer E, Kohnen R, Stiasny-Kolster K; on behalf of the Rotigotine SP710 Study Group. One year open-label safety and efficacy trial with rotigotine transdermal patch in moderate to severe idiopathic restless legs syndrome.SLEEP MED. 2008;9(8):865-873.

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Oertel WH, Benes H, Garcia-Borreguero D, Geisler P, Högl B, Saletu B, Trenkwalder C, Sommerville KW, Schollmayer E, Kohnen R, Stiasny-Kolster K; Rotigotine SP 709 Study Group.Efficacy of rotigotine transdermal system in severe restless legs syndrome: a randomized, double-blind, placebo-controlled, six-week dose-finding trial in Europe.
SLEEP MED. 2008;9(3):228-39.

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Oertel WH, Benes H, Garcia-Borreguero D, Geisler P, Högl B, Trenkwalder C,Tacken I, Schollmayer E, Kohnen R, Stiasny-Kolster K; Rotigotine SP710 Study Group. One year open-label safety and efficacy trial with rotigotine transdermal patch inmoderate to severe idiopathic restless legs syndrome.SLEEP MED. 2008;9(8):865-73.

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Trenkwalder C, Benes H, Poewe W, Oertel WH, Garcia-Borreguero D, de Weerd AW,Ferini-Strambi L, Montagna P, Odin P, Stiasny-Kolster K, Högl B, Chaudhuri KR,Partinen M, Schollmayer E, Kohnen R; SP790 Study Group.Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: arandomised, double-blind, placebo-controlled trial.LANCET NEUROL. 2008 Jul;7(7):595-604.

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Oertel WH, Benes H, Garcia-Borreguero D, Geisler P, Högl B, Saletu B, Trenkwalder C, Sommerville KW, Schollmayer E, Kohnen R, Stiasny-Kolster K; Rotigotine SP 709 Study Group.
Efficacy of rotigotine transdermal system in severe restless legs syndrome: arandomized, double-blind, placebo-controlled, six-week dose-finding trial in Europe.SLEEP MED. 2008 Mar;9(3):228-39.

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Trenkwalder C, Benes H, Poewe W, Oertel WH, Garcia-Borreguero D, de Weerd AW, Ferini-Strambi L, Montagna P, Odin P, Stiasny-Kolster K, Högl B, Chaudhuri KR,Partinen M, Schollmayer E, Kohnen R; SP790 Study Group. Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised, double-blind, placebo-controlled trial. LANCET NEUROL. 2008;7(7):595-604.

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Pevernagie D, Stanley N, Berg S, Krieger J, Amici R, Bassetti C, Billiard M, CirignottaF, Garcia-Borreguero D, Tobler I, Fischer J; Task Force of the European SleepResearch Society.European guidelines for the certification of professionals in sleep medicine: report of the task force of the European Sleep Research Society. J SLEEP RES. 2009;18(1):136-41.

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Lammers GJ, Bassetti C, Billiard M, Black J, Broughton R, Dauvilliers Y, Strambi LF, Garcia-Borreguero D, Goswami M, Högl B, Iranzo A, Jennum P, Khatami R, Lecendreux M, Mayer G, Mignot E, Montplaisir J, Nevsimalova S, Adrados RP,Plazzi G, Scammell T, Silber M, Sonka K, Tafti M, Thorpy M. Sodium oxybate is an effective and safe treatment for narcolepsy. SLEEP MED. 2009.

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Högl B, García-Borreguero D, Kohnen R, Ferini-Strambi L, Hadjigeorgiou G, Hornyak M, de Weerd A, Happe S, Stiasny-Kolster K, Gschliesser V, Egatz R, Frauscher B, Benes H, Trenkwalder C, Hening WA, Allen RP. Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: results of a prospective multi-center study. J NEUROL. 2009

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Duncan WC, Barbato G, Fagioli I, Garcia-Borreguero D, Wehr TA. A biphasic daily pattern of slow wave activity during a two-day 90-minute sleep wake
schedule. ARCH ITAL BIOL.2009;147(4):117-30

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Williams AM, Garcia-Borreguero D. Management of restless legs syndrome augmentation. CURR TREAT OPTIONS NEUROL. 2009;11(5):327-32.

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García-Borreguero D, Lahuerta-Dal Ré J, Albares J, Zaragoza S, de Gracia M.Validated translation to Spanish of the evaluation questionnaire of patients with restless legs syndrome. NEUROLOGIA 2009;24(10):823-34.

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Pevernagie D, Stanley N, Berg S, Krieger J, Amici R, Bassetti C, Billiard M,Cirignotta F, Garcia-Borreguero D, Tobler I, Fischer J; Task Force of the European Sleep Research Society. European guidelines for the certification of professionals in sleep medicine: report of the task force of the European Sleep Research Society. J SLEEP RES. 2009;18(1):136-41.

puntito

Duncan WC, Barbato G, Fagioli I, Garcia-Borreguero D, Wehr TA.A biphasicdaily pattern of slow wave activity during a two-day 90-minute sleep wakeschedule.ARCH ITAL BIOL 2009;147(4):117-30.

puntito

Sériès F; Workshop Participants. Can improving sleep influence
sleep-disordered breathing? DRUGS. 2009;69 Suppl 2:77-91.

puntito

Williams AM, Garcia-Borreguero D. Management of restless legs syndromeaugmentation. CURR TREAT OPTIONS NEUROL 2009;11(5):327-32.

puntito

García-Borreguero D, Lahuerta-Dal Ré J, Albares J, Zaragoza S, de Gracia M. Validated translation to Spanish of the evaluation questionnaire of patients with restless legs syndrome. NEUROLOGIA. 2009;24(10):823-34.

puntito

Allen R, Chen C, Soaita A, Wohlberg C, Knapp L, Peterson BT, García-BorregueroD, Miceli J. A randomized, double-blind, 6-week, dose-ranging study of pregabalinin patients with restless legs syndrome. SLEEP MED 2010 Jun;11(6):512-9.

puntito

Miranda M, Slachevsky A, Garcia-Borreguero D. Did Immanuel Kant have dementia with Lewy bodies and REM behavior disorder? SLEEP MED 2010;11(6):586-8.

puntito

Garcia-Borreguero D, Larrosa O, Williams AM, Albares J, Pascual M, PalaciosJC, Fernandez C. Treatment of restless legs syndrome with pregabalin: Adouble-blind, placebo-controlled study. NEUROLOGY 2010 8;74(23):1897-904.

puntito

García-Borreguero D, Williams AM. Dopaminergic augmentation of restless legs syndrome.SLEEP MED REV. 2010 Mar 8. [Epub ahead of print] PubMed PMID: 20219397.

puntito

Lammers GJ, Bassetti C, Billiard M, Black J, Broughton R, Dauvilliers Y, Ferini Strambi L, Garcia-Borreguero D, Goswami M, Högl B, Iranzo A, Jennum P,Khatami R, Lecendreux M, Mayer G, Mignot E, Montplaisir J, Nevsimalova S,Peraita-Adrados R, Plazzi G, Scammell T, Silber M, Sonka K, Tafti M, Thorpy M.Sodium oxybate is an effective and safe treatment for narcolepsy. SLEEP MED. 2010;11(1):105-6.

puntito

Högl B, García-Borreguero D, Kohnen R, Ferini-Strambi L, Hadjigeorgiou G,Hornyak M, de Weerd A, Happe S, Stiasny-Kolster K, Gschliesser V, Egatz R,Frauscher B, Benes H, Trenkwalder C, Hening WA, Allen RP. Progressive developmentof augmentation during long-term treatment with levodopa in restless legssyndrome: results of a prospective multi-center study.J NEUROL 2010;257(2):230-7.

puntito

Högl B, Oertel WH, Stiasny-Kolster K, Geisler P, Beneš H, García-Borreguero D, Trenkwalder C, Poewe W, Schollmayer E, Kohnen R. Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermal patch.BMC NEUROL. 2010;10:86

puntito

Garcia-Borreguero D, Allen R, Kohnen R, Benes H, Winkelman J, Högl B, Ferini-Strambi L, Zucconi M, Trenkwalder C. Loss of response during long-term treatment of restless legs syndrome: guidelines approved by the International Restless Legs Syndrome Study Group for use in clinical trials.SLEEP MED. 2010;11(9):956-7

puntito

Oertel WH, Benes H, Garcia-Borreguero D, Högl B, Poewe W, Montagna P, Ferini-Strambi L, Sixel-Döring F, Trenkwalder C, Partinen M, Saletu B, Polo O, Fichtner A, Schollmayer E, Kohnen R, Cassel W, Penzel T, Stiasny-Kolster K. Rotigotine transdermal patch in moderate to severe idiopathic restless legs syndrome: a randomized, placebo-controlled polysomnographic study.SLEEP MED. 2010;11(9):848-56

puntito

Miranda M, Williams AM, Garcia-Borreguero D. Thomas de Quincey and his restless legs symptoms as depicted in “Confessions of an English Opium-Eater”.MOV DISORD. 2010;25(13):2006-9

puntito

Miranda M, Slachevsky A, Garcia-Borreguero D. Did Immanuel Kant have dementia with Lewy bodies and REM behavior disorder?SLEEP MED. 2010;11(6):586-8

puntito

García-Borreguero D, Williams AM. Dopaminergic augmentation of restless legs syndrome.SLEEP MED REV. 2010;14(5):339-46
Högl B, Oertel WH, Stiasny-Kolster K, Geisler P, Beneš H, García-Borreguero D,Trenkwalder C, Poewe W, Schollmayer E, Kohnen R. Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermalpatch. BMC NEUROL. 2010 28;10:86.

puntito

Garcia-Borreguero D, Allen R, Kohnen R, Benes H, Winkelman J, Högl B, Ferini-Strambi L, Zucconi M, Trenkwalder C; International Restless Legs Syndrome Study Group. Loss of response during long-term treatment of restless legssyndrome: guidelines approved by the International Restless Legs Syndrome StudyGroup for use in clinical trials. SLEEP MED. 2010;11(9):956-7.

puntito

Oertel WH, Benes H, Garcia-Borreguero D, Högl B, Poewe W, Montagna P,Ferini-Strambi L, Sixel-Döring F, Trenkwalder C, Partinen M, Saletu B, Polo O,Fichtner A, Schollmayer E, Kohnen R, Cassel W, Penzel T, Stiasny-Kolster K.Rotigotine transdermal patch in moderate to severe idiopathic restless legssyndrome: a randomized, placebo-controlled polysomnographic study. SLEEP MED.2010;11(9):848-56.

puntito

Allen R, Chen C, Soaita A, Wohlberg C, Knapp L, Peterson BT, García-BorregueroD, Miceli J. A randomized, double-blind, 6-week, dose-ranging study of pregabalinin patients with restless legs syndrome. SLEEP MED. 2010;11(6):512-9.

puntito

Garcia-Borreguero D, Larrosa O, Williams AM, Albares J, Pascual M, PalaciosJC, Fernandez C. Treatment of restless legs syndrome with pregabalin: adouble-blind, placebo-controlled study. NEUROLOGY. 2010 8;74(23):1897-904.

puntito

García-Borreguero D, Williams AM. Dopaminergic augmentation of restless legs syndrome. SLEEP MED REV. 2010 Oct;14(5):339-46. Epub 2010 Mar 12. Review.

puntito

Miranda M, Williams AM, Garcia-Borreguero D. Thomas de Quincey and hisrestless legs symptoms as depicted in “Confessions of an English Opium-Eater”.MOV DISORD. 2010 Oct 15;25(13):2006-9. Review.

puntito

Miranda M, Slachevsky A, Garcia-Borreguero D. Did Immanuel Kant have dementiawith Lewy bodies and REM behavior disorder? SLEEP MED. 2010 Jun;11(6):586-8.

puntito

Oertel WH, Benes H, Garcia-Borreguero D, Högl B, Poewe W, Montagna P,Ferini-Strambi L, Sixel-Döring F, Trenkwalder C, Partinen M, Saletu B, Polo O,Fichtner A, Schollmayer E, Kohnen R, Cassel W, Penzel T, Stiasny-Kolster K.Rotigotine transdermal patch in moderate to severe idiopathic restless legssyndrome: a randomized, placebo-controlled polysomnographic study. SLEEP MED.2010 Oct;11(9):848-56.

puntito

Garcia-Borreguero D, Allen R, Kohnen R, Benes H, Winkelman J, Högl B,
Ferini-Strambi L, Zucconi M, Trenkwalder C; International Restless Legs Syndrome Study Group. Loss of response during long-term treatment of restless legssyndrome: guidelines approved by the International Restless Legs Syndrome StudyGroup for use in clinical trials. SLEEP MED. 2010 Oct;11(9):956-7.

puntito

Högl B, Oertel WH, Stiasny-Kolster K, Geisler P, Beneš H, García-Borreguero D,Trenkwalder C, Poewe W, Schollmayer E, Kohnen R. Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermalpatch. BMC NEUROL. 2010 Sep 28;10:86.

puntito

Högl B, Garcia-Borreguero D, Trenkwalder C, Ferini-Strambi L, Hening W, Poewe W, Brenner SS, Fraessdorf M, Busse M, Albrecht S, Allen RP. Efficacy and augmentation during 6months of double-blind pramipexole for restless legs syndrome.SLEEP MED. 2011 Feb 24. [Epub ahead of print].

puntito

Garcia-Borreguero D, Stillman P, Benes H, Buschmann H, Chaudhuri KR, Gonzalez Rodriguez VM, Hogl B, Kohnen R, Monti GC, Stiasny-Kolster K, Trenkwalder C,Williams AM, Zucconi M. Algorithms for the diagnosis and treatment of restless legs syndrome in primary care. BMC NEUROL. 2011 Feb 27;11(1):28. [Epub ahead of print].

puntito

Garcia-Borreguero D, Stillman P, Benes H, Buschmann H, Chaudhuri KR, Gonzalez Rodríguez VM, Högl B, Kohnen R, Monti GC, Stiasny-Kolster K, Trenkwalder C,Williams AM, Zucconi M. Algorithms for the diagnosis and treatment of restlesslegs syndrome in primary care. BMC NEUROL. 2011 Feb 27;11:28.

puntito

Högl B, Garcia-Borreguero D, Trenkwalder C, Ferini-Strambi L, Hening W, Poewe W, Brenner SS, Fraessdorf M, Busse M, Albrecht S, Allen RP. Efficacy andaugmentation during 6 months of double-blind pramipexole for restless legssyndrome. SLEEP MED. 2011 Apr;12(4):351-60.

puntito

García-Borreguero D, Williams AM. Dopaminergic augmentation of restless legssyndrome: the scope of the problem. SLEEP MED. 2011 May;12(5):425-6.

puntito

Dauvilliers Y, Bayard S, Shneerson JM, Plazzi G, Myers AJ, Garcia-BorregueroD. High pain frequency in narcolepsy with cataplexy. SLEEP MED. 2011Jun;12(6):572-7.

puntito

Oertel W, Trenkwalder C, Beneš H, Ferini-Strambi L, Högl B, Poewe W, Stiasny-Kolster K, Fichtner A, Schollmayer E, Kohnen R, García-Borreguero D; onbehalf of the SP710 study group. Long-term safety and efficacy of rotigotinetransdermal patch for moderate-to-severe idiopathic restless legs syndrome: a5-year open-label extension study. LANCET NEUROL. 2011 Aug;10(8):710-20.

puntito

García-Borreguero D, Oertel W, Trenkwalder C; SP710 study group. Treatment of restless legs syndrome with rotigotine. LANCET NEUROL. 2011 Oct;10(10):872-3.

puntito

García-Borreguero D. From restless legs syndrome to Willis-Ekbom disease: A condition reaches full age. SLEEP MED REV.2012 Aug;16(4):281-2.

puntito

Beneš H, García-Borreguero D, Ferini-Strambi L, Schollmayer E, Fichtner A, Kohnen R. Augmentation in the treatment of restless legs syndrome with
transdermal rotigotine. SLEEP MED.2012 Jun;13(6):589-97.

puntito

García-Borreguero D, Högl B, Ferini-Strambi L, Winkelman J, Hill-Zabala C, Asgharian A, Allen R. Systematic evaluation of augmentation during treatment with ropinirole in restless legs syndrome (Willis-Ekbom disease): results from a prospective, multicenter study over 66 weeks. MOV DISORD.2012 Feb;27(2):277-83.

puntito

Tzonova D, Larrosa O, Calvo E, Granizo JJ, Williams AM, de la Llave Y,García-Borreguero D. Breakthrough symptoms during the daytime in patients with restless legs syndrome (Willis-Ekbom disease). SLEEP MED.2012 Feb;13(2):151-5.

puntito

Fischer J, Dogas Z, Bassetti CL, Berg S, Grote L, Jennum P, Levy P, Mihaicuta S, Nobili L, Riemann D, Puertas Cuesta FJ, Raschke F, Skene DJ, Stanley N,
Pevernagie D. Standard procedures for adults in accredited sleep medicine centres in Europe. J SLEEP RES. 2012;21(4):357-68.

puntito

García-Borreguero D, Högl B, Ferini-Strambi L, Winkelman J, Hill-Zabala C, Asgharian A, Allen R. Systematic evaluation of augmentation during treatment with ropinirole in restless legs syndrome (Willis-Ekbom disease): results from a prospective, multicenter study over 66 weeks. MOV DISORD. 2012;27(2):277-83.

puntito

Beneš H, García-Borreguero D, Ferini-Strambi L, Schollmayer E, Fichtner A,Kohnen R. Augmentation in the treatment of restless legs syndrome with
transdermal rotigotine. SLEEP MED.2012;13(6):589-97.

puntito

García-Borreguero D. From restless legs syndrome to Willis-Ekbom disease: a condition reaches full age. SLEEP MED REV. 2012;16(4):281-2.

puntito

Garcia-Borreguero D, Ferini-Strambi L, Kohnen R, O’Keeffe S, Trenkwalder C, Högl B, Benes H, Jennum P, Partinen M, Fer D, Montagna P, Bassetti CL, Iranzo A, Sonka K, Williams AM; European Federation of Neurological Societies; European Neurological Society; European Sleep Research Society. European guidelines on management of restless legs syndrome: report of a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society. EUR J NEUROL. 2012;19(11):1385-96.

puntito

Inoue Y, Hirata K, Hayashida K, Hattori N, Tomida T, Garcia-Borreguero D. Efficacy, safety and risk of augmentation of rotigotine for treating restless legs syndrome. PROG NEUROPSYCHOPHARMACOL BIOL PSYCHIATRY2013;40:326-33.

puntito

Dohin E, Högl B, Ferini-Strambi L, Schollmayer E, Fichtner A, Bauer L, García-Borreguero D. Safety and efficacy of rotigotine transdermal patch in
patients with restless legs syndrome: a post-hoc analysis of patients taking 1 – 3 mg/24 h for up to 5 years. EXPERT OPIN PHARMACOTHER. 2013;14(1):15-25.

puntito

Garcia-Borreguero D, Kohnen R, Boothby L, Tzonova D, Larrosa O, Dunkl E. Validation of the Multiple Suggested Immobilization Test: A Test for the
Assessment of Severity of Restless Legs Syndrome (Willis-Ekbom Disease). SLEEP2013;36(7):1101-1109.

puntito

Garcia-Borreguero D, Kohnen R, Silber MH, Winkelman JW, Earley CJ, Högl B, Manconi M, Montplaisir J, Inoue Y, Allen RP. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group. SLEEP MED.2013;14(7):675-84.

puntito

Silber MH, Becker PM, Earley C, Garcia-Borreguero D, Ondo WG; Medical Advisory Board of the Willis-Ekbom Disease Foundation. Willis-Ekbom Disease Foundation revised consensus statement on the management of restless legs syndrome. MAYO CLIN PROC. 2013;88(9):977-86.

puntito

Trenkwalder C, Beneš H, Grote L, García-Borreguero D, Högl B, Hopp M, Bosse B,Oksche A, Reimer K, Winkelmann J, Allen RP, Kohnen R; RELOXYN Study Group. Prolonged release oxycodone-naloxone for treatment of severe restless legs syndrome after failure of previous treatment: a double-blind, randomised,placebo-controlled trial with an open-label extension. LANCET NEUROL 2013;12(12):1141-50.

puntito

Penzel T, Pevernagie D, Dogas Z, Grote L, de Lacy S, Rodenbeck A, Bassetti C, Berg S, Cirignotta F, d’Ortho MP, Garcia-Borreguero D, Levy P, Nobili L, Paiva T, Peigneux P, Pollmächer T, Riemann D, Skene DJ, Zucconi M, Espie C. Catalogue of knowledge and skills forsleep medicine. J SLEEP RES. 2014;23(2):222-38.

puntito

Roth T, Arnold LM, Garcia-Borreguero D, Resnick M, Clair AG. A review of the effects of pregabalin on sleep disturbance across multiple clinical conditions.
SLEEP MED REV. 2014;18(3):261-71.

puntito

Allen RP, Chen C, Garcia-Borreguero D, Polo O, DuBrava S, Miceli J, Knapp L, Winkelman JW. Comparison of pregabalin with pramipexole for restless legs
syndrome. N ENGL J MED2014;370(7):621-31.

puntito

Garcia-Borreguero D, Patrick J, DuBrava S, Becker PM, Lankford A, Chen C, Miceli J, Knapp L, Allen RP. Pregabalin versus pramipexole: effects on sleep
disturbance in restless legs syndrome. SLEEP2014;37(4):635-43.

puntito

Garcia-Borreguero D, Williams AM. An update on restless legs syndrome (Willis-Ekbom disease): clinical features, pathogenesis and treatment. CURR OPIN NEUROL.2014;27(4):493-501.

puntito

Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, WinkelmanJW, Zucconi M, Ferri R, Trenkwalder C, Lee HB; International Restless LegsSyndrome Study Group. Restless legs syndrome/Willis-Ekbom disease diagnosticcriteria: updated International Restless Legs Syndrome Study Group (IRLSSG)consensus criteria–history, rationale, description, and significance. SLEEP MED2014;15(8):860-73.

puntito

Earley CJ, Connor J, Garcia-Borreguero D, Jenner P, Winkelman J, Zee PC, Allen R. Altered Brain iron homeostasis and dopaminergic function in Restless LegsSyndrome (Willis-Ekbom Disease). SLEEP MED. 2014;15(11):1288-1301.

puntito

Walters AS, Frauscher B, Allen R, Benes H, Chaudhuri KR, Garcia-Borreguero D, Lee HB, Picchietti DL, Trenkwalder C, Martinez-Martin P, Stebbins GT, Schrag A;members of the MDS Committee on Rating Scales. Review of Diagnostic Instrumentsfor the Restless Legs Syndrome /Willis-Ekbom Disease (RLS/WED): Critique andRecommendations. J CLIN SLEEP MED. 2014. pii: jc-00274-14. [Epub ahead of print].

puntito

Walters AS, Frauscher B, Allen R, Benes H, Chaudhuri KR, Garcia-Borreguero D, Lee HB, Picchietti DL, Trenkwalder C, Martinez-Martin P, Stebbins GT, Schrag A;members of the MDS Committee on Rating Scales. Review of Quality of LifeInstruments for the Restless Legs Syndrome /Willis-Ekbom Disease (RLS/WED):Critique and Recommendations. J CLIN SLEEP MED. 2014. pii: jc-00277-14.[Epub ahead of print].

puntito

Walters AS, Frauscher B, Allen R, Benes H, Chaudhuri KR, Garcia-Borreguero D, Lee HB, Picchietti DL, Trenkwalder C, Martinez-Martin P, Stebbins GT, Schrag A;MDS Committee on Rating Scales. Review of quality of life instruments for therestless legs syndrome/Willis-Ekbom Disease (RLS/WED): critique andrecommendations. J CLIN SLEEP MED. 2014;10(12):1351-7.

puntito

Earley CJ, Connor J, Garcia-Borreguero D, Jenner P, Winkelman J, Zee PC, AllenR. Altered Brain iron homeostasis and dopaminergic function in Restless LegsSyndrome (Willis-Ekbom Disease). SLEEP MED. 2014;15(11):1288-301.

puntito

Garcia-Borreguero D, Benitez A, Kohnen R, Allen R. Augmentation of restless leg syndrome (Willis-Ekbom disease) during long-term dopaminergic treatment.
POSTGRAD MED. 2015:1-10.